Quantitative understanding of bone loss mechanism in mice using mathematical analysis

MarwaAkao

Nagoya university

"Quantitative understanding of bone loss mechanism in mice using mathematical analysis"

Osteoporosis is a disease that affects more than 200 million people all over the world. Although its underlying mechanisms are gradually being revealed, effective treatments or preventive measures have not been established yet. This study focused on age-related osteoporosis by measuring bone mass and bone metabolism markers in mice from 4 to 52 weeks of age. We developed mathematical models describing bone metabolism and analyzed experimental data. From the result of data analysis, we quantitatively elucidated the mechanisms of bone loss. Furthermore, we conducted treatment intervention simulations by changing parameter values in mathematical models to identify effective bone metabolism pathways for increasing bone mass and new potential therapeutic strategies.
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