CDEV-03

From data to mechanisms: advancement in modeling in cell and developmental biology

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Organizers:

Keisha Cook, Anna Nelson (Clemson University), Alessandra Bonfanti (Politecnico di Milano) Giulia Celora (University of Oxford) Kelsey Gasior (University of Notre Dame) Qixuan Wang (University of California, Riverside)

Description:

In many cell and developmental processes, both modeling and data analytic approaches are necessary in order to generate useful modeling predictions to guide the design of further experiments for both validating and improving biological insight. There is an increased understanding that the application of machine learning methods can also be used to enhance common data-driven modeling techniques, including parameter and equation inference, classification, and sensitivity analysis. The speakers in this session will discuss how differential equation models, stochastic models, and methods from machine learning can be combined to address questions related to cell growth, intracellular transport, cell differentiation, cell migration, and tissue development. The speakers will highlight current research progress and challenges associated with combining modeling and inference approaches in cell and developmental biology.

Diversity Statement:

The goal of this minisymposium is to create a welcoming space for early career mathematicians in cell and developmental biology to meet other participants from diverse backgrounds; gender, race, ethnicity, and socioeconomic status. We will promote open discussions after each talk, where each attendee will contribute their personal insights on these topics. The organizers will ensure an inclusive and supportive environment for participants.



Khanh Dao Duc (University of British Columbia)

"Quantifying the organization and dynamics of cell morphology in Mycobacteria from Long-Term Time-Lapse Atomic Force Microscopy"



Peijie Zhou (Peking University)

"Towards AI Virtual Cell Through Dynamical Generative Modeling of Single-cell Omics Data"



Amanda Alexander (University of Houston)

"Persistence of plasmid DNA in spatially organized bacterial populations"



Grace McLaughlin (UNC Chapel Hill)

"Modeling Asynchronous Nuclear Division in Fungal Cells"



Anna Nelson (University of New Mexico)

"Modeling mechanisms of microtubule dynamics in living neurons"



Merlin Pelz (University of Minnesota)

"Effect of compartmentalization: synchronization and symmetry-breaking of diffusively coupled cells in 2-D and 3-D"



Ying Zhang (Northeastern University)

"Why do cells migrate collectively in different modes?"



Sharon Lubkin (North Carolina State University)

"Differential growth in stomach bending: a continuum approach"



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Annual Meeting for the Society for Mathematical Biology, 2025.