Modeling the Role of Geometry and Topology in Shaping Cell Behavior, Function, and Tissue Patterns

Organizers:

Fabian Spill (University of Birmingham), Anotida Madzvamuse, University of British Columbia

Description:

Cell and tissue architecture, defined by both geometry and topology, plays a central role in determining cellular behavior and function. From the spatial organization of organelles to large-scale tissue patterns, structural constraints influence intracellular dynamics, mechanical properties, and signaling pathways. This minisymposium will highlight advances in mathematical and computational modeling that reveal how geometric and topological features govern processes such as cell polarization, migration, division, and tissue morphogenesis. Talks will explore approaches including reaction-diffusion systems, mechanical models, and network-based methods to infer functional outcomes from structural properties. By integrating theoretical frameworks with experimental data, this session aims to uncover fundamental principles linking form and function across scales, offering new insights into the physical basis of biological organization.

Diversity Statement:

To promote broad representation and inclusivity in our mini-symposium, we have selected speakers and organizers from diverse backgrounds, institutions across multiple regions, and various career stages. Our lineup includes representatives from five continents, spanning roles from postdoctoral researchers to full professors, with a particular emphasis on early-career researchers, including four postdoctoral fellows