CDEV-07

Modeling cell migration at multiple scales

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Organizers:

Jared Barber (Indiana University Indianapolis), Luoding Zhu

Description:

Cell migration is inarguably an important process as it plays a major role in embryo development, inflammation, cancer metastasis, wound healing, and other processes. It is an inherently complex multi-scale process. While most molecular parts and corresponding processes involved in cell migration are well-characterized, it is not yet clear how such parts and processes connect and interact in order to produce the migratory motion that we typically see. For this reason, research on cell migration has continued with mathematical modeling yielding major contributions on the way. To explore how part/process interactions affect migration at multiple scales, we have invited speakers to share their work with talks that use mathematical models to explore important factors for cell migration including factors on the subcellular, cellular, and collective migration scales.

Diversity Statement:

Our cell migration talks focus on 3 topics, not just one: subcellular dynamics, cell-level dynamics, and multi/collective cell dynamics. We have an undergraduate and graduate student, two postdocs, and four professors of varying seniority. Speakers come from the US, Korea, Canada, Germany, and Israel. They have official affiliations with math, physics and astronomy, chemical and biological physics, and interdisciplinary life sciences. We would love to bring this diverse collection together.



Anotida Madzavamuse

"A mechanobiochemical model for 3D single cell migration"



Calina Copos

"Breakdown of the Scallop theorem in confined single cell locomotion"



Emiliano Perez Ipina

"Cell motility self-regulated by secreted footprints"



Yuehui Xu

"Effects of the cytoskeleton on cell migration"



Yangjin Kim

"Mathematical modeling of glioma cell migration on blood vessels via Cl- chanel-mediated cell deformation and biophysical interaction with astrocytes"



Sebastian Aland

"How cell surface processes and patterns drive how cells choose their travel direction in channels"



Shubhadeep Sadhukhan

"Modelling lamellipodia-driven single-cell migration and interaction with external barriers"



Jianda Du

"The Effect of Curvature in Mathematical Models of Cell Migration"



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Annual Meeting for the Society for Mathematical Biology, 2025.