Mathematical Model for Gene Drive Mosquito Releae On Principe Island

SureniWickramasooriya

University of California - Davis

"Mathematical Model for Gene Drive Mosquito Releae On Principe Island"

Genetically engineered mosquitoes (GEMs) offer a promising malaria control strategy, yet their ecological interactions, dispersal, and long-term effects remain uncertain. Accurate modeling is essential to optimize GEM release strategies and assess their effectiveness in natural ecosystems. This study presents a high-performance, exascale agent-based model (ABM) simulating gene drive dynamics in wild mosquito populations. Incorporating mosquito population dynamics, spatial ecology, and genotype inheritance, the model provides insights into optimizing release timing, locations, and dispersal strategies. Our findings indicate that under optimal dispersal conditions, GEMs can achieve a 95% prevalence in wild populations within 112 days. Furthermore, our findings indicate that strategically coordinating GEM releases across multiple sites does not significantly impact gene drive establishment on the island. By capturing mosquito behaviors and movement in heterogeneous environments, this ABM serves as a powerful tool for evaluating GEM interventions, supporting evidence-based malaria control strategies, and enhancing ecological understanding of gene drive propagation..
Additional authors:

---