Antibiotic Resistance and Dosing in Bacterial Biofilms

AdnanKhan

Lahore University of Management Sciences

"Antibiotic Resistance and Dosing in Bacterial Biofilms"

In this talk, we will present effective antibiotic regimens in the presence of drug-resistant bacteria in biofilms. We begin by discussing models of in-vivo antimicrobial resistance transfer within bacterial biofilms, focusing on various one-dimensional biofilm models. Our approach includes modeling resistance acquisition through horizontal gene transfer between resistant and susceptible strains while also accounting for the role of persistor cells. We examine the effects of periodic antibiotic dosing at a constant level, showing that it may not always lead to bacterial eradication. To address this challenge, we utilize a numerical optimization algorithm to determine the optimal antibiotic dosing strategy. Additionally, we analyze how changes in different model parameters impact the qualitative behavior of the optimal dosing regimen.
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