A Bayesian inference framework to calibrate one-dimensional velocity-jump models for single-agent motion using discrete-time noisy data

AriannaCeccarelli

University of Oxford

"A Bayesian inference framework to calibrate one-dimensional velocity-jump models for single-agent motion using discrete-time noisy data"

Advances in experimental techniques allow the collection of high-resolution spatio-temporal data that track individual motile entities over time and could be used to calibrate mathematical models of individual motility. However, experimental data is intrinsically discrete and noisy, and these characteristics complicate the effective calibration of models for individual motion. We consider individuals whose movement can be described by velocity-jump models in one spatial dimension, characterised by successive Markovian transitions between a network of n states, each with a specified velocity and a fixed rate of switching to every other state. We develop a Bayesian framework to calibrate these models to discrete and noisy data, which uses a likelihood consisting of approximations to the model solutions which we previously obtained. We apply the framework to recover the model parameters of simulated data, including the probabilities of switching to every other state. Moreover, we test the ability of the framework to select the most appropriate model to fit the data, including comparisons varying the number of states n.
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