MFBM-27

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Organizers:

Dhananjay Bhaskar (Yale University), Bernadette Stolz-Pretzer

Description:

The increasing complexity of modern biomedical datasets necessitates advanced mathematical frameworks that reveal intrinsic structures beyond traditional statistical approaches. Geometrical and topological methods provide powerful tools to extract robust and interpretable patterns from high-dimensional, noisy, and multimodal data, enabling more effective data-driven modeling. This minisymposium will explore recent advances at the intersection of geometry, topology, and mathematical modeling, highlighting techniques such as persistent homology, sheaf theory, optimal transport, manifold learning, and geometric deep learning. Speakers will present applications to diverse fields ranging from oncology, liver disease to neuroscience, demonstrating how these methods enhance our understanding of complex biological systems, disease progression, and cellular organization. By fostering interdisciplinary dialogue, this session aims to showcase novel approaches that push the boundaries of data-driven discovery and advance mathematical techniques for biomedical research.

Diversity Statement:

We recognize the importance of diversity in academic discourse and are committed to fostering an inclusive and representative minisymposium. To this end, we have carefully selected speakers representing multiple career stages, including PhD students, postdocs, early-career researchers, and established faculty. We have made a concerted effort to ensure a balanced speaker lineup that reflects a broad range of perspectives and experiences.



Jian Tang (Mila - Quebec AI Institute)

"Geometric deep learning for protein design"



Katherine Benjamin (University of Oxford)

"Topological methods for subcellular spatial transcriptomics"



Veronica Ciocanel (Duke University)

"Unraveling actin filament aster and ring structures using topological data analysis"



Darrick Lee (University of Edinburgh)

"Geometric aspects of lead-lag phenomena"



Nan Wu (University of Texas at Dallas)

"Adaptive Bayesian regression on high dimensional data with low intrinsic dimensionality"



Eunbi Park (National Cancer Institute)

"Topological data analysis of pattern formation of human induced pluripotent stem cell colonies"



Dhananjay Bhaskar (Yale University)

"Mapping the landscape of protein conformations in molecular dynamics"



Bernadette Stolz (Max Planck Institute of Biochemistry)

"Relational persistent homology for multispecies data with application to the tumor microenvironment"



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Annual Meeting for the Society for Mathematical Biology, 2025.