Quantitative Systems Pharmacology: Linking mathematical biology to model informed drug development (MIDD) - Pharmacometrics Subgroup

Organizers:

Marissa Renardy (Quantitative Systems Pharmacology, GSK), Kathryn G. Link, Quantitative Systems Pharmacology, Pfizer Inc.

Description:

Quantitative systems pharmacology (QSP) combines mathematical and computational modeling tools with mechanistic understanding of biology and pharmacology to guide drug discovery and development. QSP is used in the pharmaceutical industry to accelerate and de-risk drug discovery and development across multiple stages, from target discovery/validation to clinical trial design to lifecycle management. In recent years, QSP has been increasingly used in regulatory submissions for clinical trials across many therapeutic areas (PMID:34734497). In this session, speakers will present recent advances and perspectives in the field of QSP. This minisymposia will have two sessions. The first session will consist of four technical talks. The second session will be comprised of three technical talks and an industry panel discussion with prepared and audience-driven questions.

Diversity Statement:

The proposed sessions embody innovation and diversity in both the techniques presented and the backgrounds/research interests of the speakers. The industry and academic contributors represent a range of career stages, spanning from trainees to field leaders. The breadth of research interests includes variety among disease indications and therapeutic interventions. This session will increase visibility of these techniques to support QSP development and foster new industry-academic collaborations.