PS01 MEPI-28

Modelling the heterogeneity of C. burnetii shedding patterns in cattle and possible control strategies

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Zhao Mei Zheng

The University of Sydney, Sydney, Australia
"Modelling the heterogeneity of C. burnetii shedding patterns in cattle and possible control strategies"
Coxiella burnetii is the zoonotic bacterium responsible for coxiellosis in animals and Q fever in humans. Ruminants such as goats, sheep and cattle are important reservoirs of C. burnetii. The heterogeneity of shedding dynamics of C. burnetii has been described in previous field sampling studies but gaps in knowledge exist in regard to variations in shedding patterns across gestation and lactation cycles. We developed a stochastic computer simulation to explore possible heterogenous transmission dynamics and the impact of supershedder cows in a herd. The model was parameterised on values from peer-reviewed literature. We applied the model to compare different control strategies, including quarantine, intense environmental cleaning, breeding ban, culling and vaccination of animals.



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Annual Meeting for the Society for Mathematical Biology, 2025.