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Organizers:
Eric Cytrynbaum (University of British Columbia), Tim Tian (University of British Columbia)
Description:
Many cellular processes depend heavily on the dynamics and mechanics of the cytoskeleton. Actin and microtubules are non-equilibrium linear polymers whose localization, density, crosslinking and orientation are often controlled by the cell for various critical purposes (cell division, cell growth, motility etc.). Their influence involves both chemical properties (e.g. assembly dynamics, reactions with associated enzymes) and mechanical ones. In this session, we highlight some of the latest mathematical modelling efforts to understand the influence of the cytoskeleton on various cellular behaviours. We particularly highlight agent-based models which, while computationally intensive to simulate, allow for a detailed representation of geometry, mechanics and interactions.
Diversity Statement:
We believe our speakers are diverse in career stage, ethnicity, and gender. Half are PhD students, half are women, and half are visible minorities.
Hannah Scanlon (Duke University)
"Mechanisms of Microtubule Polarity Regulation in Neurons"
Calina Copos (Northeastern University)
"Molecular underpinnings of a biphasic force response during cell stretching"
Tim Tian (University of British Columbia)
"Organization of Plant Cortical Microtubules"
Taeyoon Kim (Purdue University)
"Reconstituting the Mechanical and Dynamic Behaviors of the Actin Cytoskeleton"
