Type I interferons (IFNs) are cytokines with both antiviral properties and protective roles in innate immune responses to viral infection. They induce an antiviral cellular state and link innate and adaptive immune responses. Yet, viruses have evolved different strategies to inhibit such host responses. One of them is the existence of viral proteins which subvert type I IFN responses to allow quick and successful viral replication, thus, sustaining the infection within a host. We propose mathematical models to characterise the intra-cellular mechanisms involved in viral protein antagonism of type I IFN responses, and compare three different molecular inhibition strategies. We study the Ebola viral protein, VP35, with this mathematical approach. Approximate Bayesian computation sequential Monte Carlo, together with experimental data and the mathematical models proposed, are used to perform model calibration, as well as model selection of the different hypotheses considered. Finally, we assess if model parameters are identifiable and discuss how such identifiability can be improved with new experimental data.
Immunobiology and Infection Subgroup (IMMU)
Ad hoc subgroup meeting room(reserved for subgroup activities):TBD
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Sub-group minisymposia
Timeblock: MS01
IMMU-03
(Part 1)
Immune Responses to Viral Infections and Vaccines
Timeblock: MS01
IMMU-03
(Part 1)
Organized by: Veronika I. Zarnitsyna (Emory University), Esteban Hernandez Vargas, University of Idaho
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Macauley Locke Los Alamos National Laboratory "Quantification of Type I Interferon Inhibition by Viral Proteins: Ebola Virus as a Case Study"
- Jane Marie Heffernan York University "COVID-19 Vaccination in HIV+ Individuals"
- Jason E. Shoemaker University of Pittsburgh "A More Severe Influenza Infection in Female Mice Relative to Male is Characterized by Early Viral Production and Increased Innate Immune Activity"
- Veronika I. Zarnitsyna Emory University School of Medicien "Challenges in Evaluating Vaccine-Induced Protection Against Severe Disease"
Timeblock: MS04
IMMU-01
(Part 1)
New approaches to infectious disease immunity for model-informed vaccine development
Timeblock: MS04
IMMU-01
(Part 1)
Organized by: Terry Easlick (Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine), Morgan Craig, Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Jane Heffernan York University "The Malaria Parasite Life-Cycle"
- Solène Hegarty-Cremer Université de Montréal "Analysing Immune Dysregulation in Vitamin A Deficient Mice During Influenza A Infection"
- Stanca M. Ciupe Virginia Tech "Immune system onset and reaction against viral diseases"
- Terry Easlick Université de Montréal "Stochastic Methods for modelling antigen-specific cell-mediated immune response"
Timeblock: MS04
IMMU-04
(Part 1)
Multiscale modelling in infectious diseases
Timeblock: MS04
IMMU-04
(Part 1)
Organized by: Dr Macauely Locke (Los Alamos National Laboratory), Dr Jasmine Kreig, Dr Aurelien Marc, Los Alamos National Laboratory
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Aurelien Marc Los Alamos National Laboratory "Modelling shows novel polymerase inhibitor AT-511 (Bemnifosbuvir) demonstrates dual activity against both production and assembly/secretion of hepatitis C virus."
- Nathanael Hoze IAME "Integrating multiscale mathematical modeling and serology to unravel antibody dynamics and infection risk"
- Quiyana Murphy Virginia tech "Understanding antibody durability and magnitude following vaccination against SARS-CoV-2"
- Grant Lythe University of Leeds "Models of bursting and budding"
Timeblock: MS05
IMMU-03
(Part 2)
Immune Responses to Viral Infections and Vaccines
Timeblock: MS05
IMMU-03
(Part 2)
Organized by: Veronika I. Zarnitsyna (Emory University), Esteban Hernandez Vargas, University of Idaho
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Grant Lythe University of Leeds "TCR repertoire and cross-reactivity"
- Dylan Hull-Nye Washington State University "Derivation of mathematical relationship between cytotoxic T lymphocyte (CTL) and antibody production rates for immune control in lentiviral infection"
- Alexis Erich S. Almocera University of the Philippines Mindanao "Hopf Bifurcations Unravel Complex Antibody Dynamics in COVID-19 Patients"
- Reagan Johnson University of Idaho "Modeling Rhinovirus mediated protection against lethal influenza"
Timeblock: MS06
IMMU-02
In host Viral Dynamics
Timeblock: MS06
IMMU-02
Organized by: Esteban A. Hernandez-Vargas (University of Idaho), Veronika Zarnitsyna, Emory University
- Esteban Hernandez Vargas University of Idaho "CrossLabFit: Enhancing parameter fitting in viral dynamics through cross-laboratory qualitative integration"
- Hana Dobrovolny Texas Christian University "Time-varying viral production in virus dynamics models"
- Timon Kapischke University Medicine Greifswald Greifswald "Mathematical Modeling and Analysis of Factors Influencing the Intracellular Replication of SARS-CoV-2"
- Lubna Pinky Meharry Medical College "Modeling how virus-virus interference can affect population-level transmission dynamics"
Timeblock: MS08
IMMU-04
(Part 2)
Multiscale modelling in infectious diseases
Timeblock: MS08
IMMU-04
(Part 2)
Organized by: Dr Macauely Locke (Los Alamos National Laboratory), Dr Jasmine Kreig, Dr Aurelien Marc, Los Alamos National Laboratory
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Jasmine A.F. Kreig Los Alamos National Laboratory "A stochastic model of HIV viral rebound after treatment interruption"
- Sarafa Adewale Iyaniwura Fred Hutch "Understanding the effectiveness of a capsid assembly modulator (CAM) in the treatment of chronic HBV infection"
- Paolo Bosetti Institut Pasteur "Accounting for epidemic reintroductions in infectious disease modelling"
- Mason Lacy Queensland University of Technology "Modelling T cell expansion in immune cell-mimicking scaffolds for adoptive cell therapy"
Timeblock: MS09
IMMU-01
(Part 2)
New approaches to infectious disease immunity for model-informed vaccine development
Timeblock: MS09
IMMU-01
(Part 2)
Organized by: Terry Easlick (Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine), Morgan Craig, Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Mélanie Prague Université de Bordeaux/INRIA "Mechanistic Model of initial and persisting antibody response following Ebola vaccination: application to the PREVAC trial."
- Elizabeth Amona Virginia Commonwealth University "Studying Disease Reinfection Rates, Vaccine Efficacy and the Timing of Vaccine Rollout in the context of Infectious Diseases"
- Cailan Jeynes-Smith University of Tennessee Health Science Centre "Dissecting Cytokine Production: Integrating Subset-Specific Data into Immunological Models"
- Jonah Hall University of British Columbia/BC Children's Hospital Research Institute "Optimization of Pertussis Immunization Using Mathematical Modeling"
Sub-group contributed talks
Timeblock: CT01
IMMU-01
IMMU Subgroup Contributed Talks
Timeblock: CT01
IMMU-01
- Daniel Rüdiger Max Planck Institute Magdeburg "The secrets of “OP7”, an influenza DIP: mathematical model, impact of mutations and antiviral mechanisms"
- Ying Xie Kyoto University "Antihistamine Efficacy in Relation to the Morphology of Skin Eruptions in Chronic Spontaneous Urticaria"
- Madeleine Gastonguay Institute for Computational Medicine, Johns Hopkins University "Viral rebound kinetics following single and combination immunotherapy for HIV/SIV"
Timeblock: CT02
IMMU-01
IMMU Subgroup Contributed Talks
Timeblock: CT02
IMMU-01
- Hwai-Ray Tung University of Utah "Missed an antibiotic dose - what to do?"
- Montana Ferita University of Utah "Surfing the Actin Wave: Mathematical Modeling of Natural Killer Cell Synapse Formation"
- Madeleine Gastonguay Johns Hopkins University "Quantifying the dynamics of Kaposi’s sarcoma-associated herpesvirus persistence"
- Kathryn Lynch University of Utah "Genetic regulation of vibrio vulnificus hemolysin drives population heterogeneity"
Timeblock: CT03
IMMU-01
IMMU Subgroup Contributed Talks
Timeblock: CT03
IMMU-01
- Jonah Hall UBC "Optimization of Pertussis Immunization Using Mathematical Models"
- Adnan Khan Lahore University of Management Sciences "Antibiotic Resistance and Dosing in Bacterial Biofilms"
- Peter Rashkov Institute of Mathematics and Informatics, Bulgarian Academy of Science, Sofia, Bulgaria "Towards a mathematical model of the methotrexate effect on immunogenicity to adalimumab in axial spondyloarthritis"
Sub-group poster presentations
IMMU Posters