In host Viral Dynamics

Organizers:

Esteban A. Hernandez-Vargas (University of Idaho), Veronika Zarnitsyna, Emory University

Description:

Understanding the complex dynamics of viral infections requires integrating experimental data with mathematical and computational models that capture both intracellular and cell-level processes. This mini-symposium will explore recent advances in modeling SARS-CoV-2 and other respiratory viruses to improve predictions of infection dynamics, antiviral efficacy, and viral interactions. Presentations will examine how clinical trial simulations can refine antiviral potency assessments, addressing discrepancies between polymerase chain reaction (PCR) measurements and actual viral clearance. The discussion will also focus on time-dependent viral production rates and their implications for within-host infection models. At the intracellular level, mechanistic models of SARS-CoV-2 replication will provide insights into key bottlenecks in the viral life cycle and potential therapeutic targets. Finally, the symposium will explore models of viral-viral coinfections in the respiratory tract, highlighting how interactions between different pathogens can shape disease progression and treatment responses. By bridging theoretical and clinical perspectives, this session aims to refine our understanding of viral infections and inform more effective antiviral strategies.

Diversity Statement:

Our minisymposium highlights diversity in gender, career stage, and geography. Featuring two male and two female speakers, we ensure balanced representation. Additionally, our speakers span early-career to senior researchers, fostering mentorship and knowledge exchange. Geographically, they come from different institutions across regions, enriching perspectives. This inclusive approach promotes interdisciplinary dialogue and innovation in our field.