Organizers:
Fabian Spill (University of Birmingham), Anotida Madzvamuse, University of British Columbia
Description:
Cell and tissue architecture, defined by both geometry and topology, plays a central role in determining cellular behavior and function. From the spatial organization of organelles to large-scale tissue patterns, structural constraints influence intracellular dynamics, mechanical properties, and signaling pathways. This minisymposium will highlight advances in mathematical and computational modeling that reveal how geometric and topological features govern processes such as cell polarization, migration, division, and tissue morphogenesis. Talks will explore approaches including reaction-diffusion systems, mechanical models, and network-based methods to infer functional outcomes from structural properties. By integrating theoretical frameworks with experimental data, this session aims to uncover fundamental principles linking form and function across scales, offering new insights into the physical basis of biological organization.
Gulsemay Yigit
The University of British Columbia"Reaction-Diffusion Systems in Bilayer Geometries with Variable Width"
Maryam Parvizi
University of Birmingham"A Mathematical Energy-Based Framework for Modeling Single-Cell Epithelial Migration"
Stephanie Portet
University of Manitoba"Transport of intermediate filaments in cells"
Vijay Rajagopal
The University of Melbourne"MitoMimics: Synthetic microscopy timelapse data for zero-annotation AI segmentation and tracking of mitochondrial dynamics"
