Blood vessel adaptation plays an important role in maintaining healthy and well-oxygenated tissue throughout the body. This is especially true for the brain. To better characterize how blood flow changes when the brain suffers a major arterial occlusion (e.g. during a stroke) and to identify major factors that may affect flow restoration to downstream regions, we created a mathematical model of blood flow in the brain. The network is modeled as multiple larger vessels interconnected with multiple compartments of smaller vessels with each compartment consisting of identical vessels situated in parallel. The model further includes vessel adaptation in response to changes in pressure (myogenic response), wall shear stress (shear response), and oxygen saturation (metabolic response). By varying tissue oxygen demand and incoming pressure, we are able to identify that the number of collateral vessels moving flow from unobstructed to obstructed regions is a major factor. We also predicted a loss of normal function particularly reflected by a shift in the “autoregulation curve”, a curve that reflects the ability of vessels to reasonably respond to increases in pressure. Such results were consistent with experiment and reinforce the appropriateness of treatments that raise flow and oxygenation by minimizing tissue oxygen demand and raising vascular pressure.
Contributed talk session: CT01
Tuesday, July 15 at 2:30pm
Contributed talk session: CT01
Timeblock: CT01
CARD-01
CARD Subgroup Contributed Talks
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CARD-01
- Jared Barber IU Indianapolis "Mathematical model of blood flow in the brain after a major arterial occlusion."
- Cory Brunson University of Florida "Testing hypotheses of glomerular capillary development with geometric and topological data analysis"
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CDEV-01
CDEV Subgroup Contributed Talks
Timeblock: CT01
CDEV-01
- Holly Huber University of Southern California "Multiscale Probabilistic Modeling - A Bayesian Approach to Augment Mechanistic Models of Cell Signaling with Machine-Learning Predictions of Binding Affinity"
- Chongming Li Queen's University Department of Mathematics and Statistics "Well-Posedness and Stability Analysis of a PDE-ODE Model for the Evolution of Bacterial Persisters"
- neda khodabakhsh joniani Mrs She "A Voronoi Cell-Based model for Corneal epithelial cells"
- Shikun Nie UBC "Estimating Rate Parameters in Super-Resolution Imaging via Hidden Continuous Markov Chains with Discretized Emissions"
- somdata sina INDIAN INSTITUTE OF SCIENCE EDUCATION RESEARCH (IISER) KOLKATA, INDIA "using networks for modelling three-dimensional structures of proteins"
- Nathan Smyers University of North Carolina at Chapel Hill "From Data to Dynamics: Uncovering Cell Signaling Networks with Physics-Informed Machine Learning"
- Anna Nelson University of New Mexico "Modeling mechanisms of microtubule dynamics and polarity in neurons"
- Dietmar Oelz The University of Queensland "Mechanochemical pattern formation in Hydra"
- Katrin Schröder Goethe University "mRNA Translation Stalling in Single-Codon Resolution Monte-Carlo Ribosome Flow Model Simulations"
- Adriana Zanca The University of Melbourne "Cell fate through the lens of random dynamical systems"
- Supriya Bidanta Indiana University "Understanding the role of hydration in aging of skin epidermis through a modeling cell-cell communication"
- Samuel Johnson University of Oxford "Mathematical Optimisation of Actin-Driven Protrusion Formation in Eukaryotic Chemotaxis"
Timeblock: CT01
CDEV-02
CDEV Subgroup Contributed Talks
Timeblock: CT01
CDEV-02
- Nathan Smyers University of North Carolina at Chapel Hill "From Data to Dynamics: Uncovering Cell Signaling Networks with Physics-Informed Machine Learning"
- Anna Nelson University of New Mexico "Modeling mechanisms of microtubule dynamics and polarity in neurons"
- Dietmar Oelz The University of Queensland "Mechanochemical pattern formation in Hydra"
- Katrin Schröder Goethe University "mRNA Translation Stalling in Single-Codon Resolution Monte-Carlo Ribosome Flow Model Simulations"
- Adriana Zanca The University of Melbourne "Cell fate through the lens of random dynamical systems"
Timeblock: CT01
CDEV-03
CDEV Subgroup Contributed Talks
Timeblock: CT01
CDEV-03
- Supriya Bidanta Indiana University "Understanding the role of hydration in aging of skin epidermis through a modeling cell-cell communication"
- Samuel Johnson University of Oxford "Mathematical Optimisation of Actin-Driven Protrusion Formation in Eukaryotic Chemotaxis"
Timeblock: CT01
ECOP-01
ECOP Subgroup Contributed Talks
Timeblock: CT01
ECOP-01
- Maria Kuruvilla University of Victoria "Quantifying the Impact of Forest Harvesting on Chum and Pink Salmon Populations in Coastal BC"
- Morgan Lavenstein Bendall University of California, Merced "Exploring Climate-Driven Population Changes in Aster Leafhoppers Using Age-Structured Models"
- Alexander Moffett Northeastern University "Detecting selection with a null model of gene order evolution"
- Silas Poloni University of Victoria "Evolutionary dynamics at the leading edge of biological invasions"
- Jacob Serpico University of Alberta "Decoding the spatial spread of cyanobacterial blooms in an epilimnion"
- Farshad Shirani Emory University "Environmental “Knees” and “Wiggles” as Stabilizers of Species Range Limits Set by Interspecific Competition"
- Maximilian Strobl Cleveland Clinic "Towards Quantitative and Predictive Models of Tumour Ecology: A Framework for Calibrating Evolutionary Game Theory with Experimental Data"
- Sureni Wickramasooriya University of California - Davis "Mathematical Model for Gene Drive Mosquito Releae On Principe Island"
- Brian Zambrano University of Alberta "Cyanobacteria Hot Spot Detection Integrating Remote Sensing Data with Convolutional and Kolmogorov-Arnold Networks"
- Jia Zhao University of Alabama "Experimental and theoretical investigations of rotating algae biofilm reactors (RABRs): Areal productivity, nutrient recovery, and energy efficiency"
- Joseph Baafi Memorial University of Newfoundland "Effect of Climate Warming on Mosquito Population Dynamics in Newfoundland"
- Alexander Browning University of Melbourne "Heterogeneity in temporally fluctuating environments"
- Kyunghan Choi Postdoctoral Research Fellow/ University of Alberta "Animal movement models with spatiotemporal memory"
Timeblock: CT01
ECOP-02
ECOP Subgroup Contributed Talks
Timeblock: CT01
ECOP-02
- Farshad Shirani Emory University "Environmental “Knees” and “Wiggles” as Stabilizers of Species Range Limits Set by Interspecific Competition"
- Maximilian Strobl Cleveland Clinic "Towards Quantitative and Predictive Models of Tumour Ecology: A Framework for Calibrating Evolutionary Game Theory with Experimental Data"
- Sureni Wickramasooriya University of California - Davis "Mathematical Model for Gene Drive Mosquito Releae On Principe Island"
- Brian Zambrano University of Alberta "Cyanobacteria Hot Spot Detection Integrating Remote Sensing Data with Convolutional and Kolmogorov-Arnold Networks"
- Jia Zhao University of Alabama "Experimental and theoretical investigations of rotating algae biofilm reactors (RABRs): Areal productivity, nutrient recovery, and energy efficiency"
Timeblock: CT01
ECOP-03
ECOP Subgroup Contributed Talks
Timeblock: CT01
ECOP-03
- Joseph Baafi Memorial University of Newfoundland "Effect of Climate Warming on Mosquito Population Dynamics in Newfoundland"
- Alexander Browning University of Melbourne "Heterogeneity in temporally fluctuating environments"
- Kyunghan Choi Postdoctoral Research Fellow/ University of Alberta "Animal movement models with spatiotemporal memory"
Timeblock: CT01
IMMU-01
IMMU Subgroup Contributed Talks
Timeblock: CT01
IMMU-01
- Daniel Rüdiger Max Planck Institute Magdeburg "The secrets of “OP7”, an influenza DIP: mathematical model, impact of mutations and antiviral mechanisms"
- Ying Xie Kyoto University "Antihistamine Efficacy in Relation to the Morphology of Skin Eruptions in Chronic Spontaneous Urticaria"
- Madeleine Gastonguay Institute for Computational Medicine, Johns Hopkins University "Viral rebound kinetics following single and combination immunotherapy for HIV/SIV"
Timeblock: CT01
MEPI-01
MEPI Subgroup Contributed Talks
Timeblock: CT01
MEPI-01
- Lindsay Keegan University of Utah "A theoretical framework to quantify the tradeoff between individual and population benefits of expanded antibiotic use"
- Youngsuk Ko Yale University "Effective Vaccination Strategies Against Dengue in Brazil: A Mathematical Modeling Approach Incorporating Spatial and Demographic Heterogeneities"
- Francisca Olajide University of Ottawa "From process to structure of EWSs"
- Marwa Tuffaha York University "Counterfactual COVID-19: Modeling Alternative Mitigation and Vaccination Policies for Canada"
Timeblock: CT01
MFBM-01
MFBM Subgroup Contributed Talks
Timeblock: CT01
MFBM-01
- Arianna Ceccarelli University of Oxford "A Bayesian inference framework to calibrate one-dimensional velocity-jump models for single-agent motion using discrete-time noisy data"
Timeblock: CT01
NEUR-01
NEUR Subgroup Contributed Talks
Timeblock: CT01
NEUR-01
- Alexander Ginsberg The University of Utah, Department of Mathematics "A predictive propensity measure to enter REM sleep"
Timeblock: CT01
ONCO-01
ONCO Subgroup Contributed Talks
Timeblock: CT01
ONCO-01
- Gustav Lindwall Max Planck Institute for Evolutionary Biology "A Mathematical Model for Pseudo-Progression in CAR-T therapy of B-cell Lymphomas"
- Rafael Bravo University of Texas at Austin "Testing the feasibility of estimating the migration to proliferation rate ratio in glioblastoma from single time-point MRI data"
- Aaron Li University of Minnesota "Using a pharmacokinetic ctDNA shedding model to develop a biomarker of tumor response to targeted therapy"
- Ruby Nixson Mathematical Institute, University of Oxford "A structured-PDE approach to targeting a quiescent sub-population under hypoxia and anti-tumour therapies in paediatric glioma."
- Reshmi Patel The University of Texas at Austin "MRI-based mathematical modeling to predict the response of cervical cancer patients to chemoradiation"
- Pujan Shrestha Texas A&M University "An ODE-SDE Model for Ct-DNA dynamics"
- Keith Chambers University of Oxford "Adipocyte-derived lipids promote phenotypic bistability in a structured population model for melanoma growth"
- Fabian Spill University of Birmingham "Regulation of Intra- and Intercellular Metabolite Transport in Cancer Metabolism"
- Chenxu Zhu Institute for Computational Biomedicine - Disease Modeling "Machine learning-assisted mechanistic modeling to predict disease progression in acute myeloid leukemia patients"
- Veronika Hofmann Technical University of Munich "Spectral Spatial Analysis of Cancer Biopsies: Validation through in-silico data and extension to logistic growth models"
- Nicholas Lai University of Oxford "Mathematical Modelling of Tertiary Lymphoid Structures in Cancer"
Timeblock: CT01
ONCO-02
ONCO Subgroup Contributed Talks
Timeblock: CT01
ONCO-02
- Pujan Shrestha Texas A&M University "An ODE-SDE Model for Ct-DNA dynamics"
- Keith Chambers University of Oxford "Adipocyte-derived lipids promote phenotypic bistability in a structured population model for melanoma growth"
- Fabian Spill University of Birmingham "Regulation of Intra- and Intercellular Metabolite Transport in Cancer Metabolism"
- Chenxu Zhu Institute for Computational Biomedicine - Disease Modeling "Machine learning-assisted mechanistic modeling to predict disease progression in acute myeloid leukemia patients"
- Veronika Hofmann Technical University of Munich "Spectral Spatial Analysis of Cancer Biopsies: Validation through in-silico data and extension to logistic growth models"
Timeblock: CT01
ONCO-03
ONCO Subgroup Contributed Talks
Timeblock: CT01
ONCO-03
- Nicholas Lai University of Oxford "Mathematical Modelling of Tertiary Lymphoid Structures in Cancer"
Timeblock: CT01
OTHE-01
OTHE Subgroup Contributed Talks
Timeblock: CT01
OTHE-01
- Richard Foster Virginia Commonwealth University "Practical parameter identifiability of respiratory mechanics in the extremely preterm infant"
- Caleb Mayer Stanford University "Mathematical Modeling of Circadian Rhythms: Applications to Phase Prediction and Fatigue Reduction"
- Vasilis Tsilidis Department of Mathematics, University of Patras "Unveiling the Drivers of Fetal Weight Estimation: Which Ultrasound Measurements Matter Most?"