Limbal stem cell deficiency (LSCD) is an ocular disease characterized by a loss or deficiency of the stem cells in the limbus, which are vital for ensuring homeostasis of the corneal epithelium. When these stem cells are lost, the corneal epithelium breaks down becoming scarred and chronically inflamed, resulting in vision loss, chronic pain and photophobia. Treatment of LSCD takes the form of an ex-vivo cultured limbal stem cell (LSC) transplant into the affected eye. Although proven effective at restoring vision, much remains to be understood about the mechanics of corneal epithelium recovery following the LSC transplant.
Our research aims to utilise the power of statistical image analysis and mathematical modelling to answer fundamental questions about the condition of the corneal epithelium in an LSCD affected eye, the proliferation and behaviours of LSCs following transplant, and how these behaviours result in the complete restoration of the corneal epithelium. Here, we analyse IVCM images from patients with total unilateral LSCD, taken before and after LSC transplant, to explore potential quantitative diagnostic and monitoring measures of the corneal recovery process.
Minisymposia: MS04
Tuesday, July 15 at 3:50pm
Minisymposia: MS04
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CARD-02
(Part 4)
Novel multiscale and multisystem approaches to cardiovascular modeling and simulation
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CARD-02
(Part 4)
Organized by: Mitchel J. Colebank (University of South Carolina), Vijay Rajagopal, The University of Melbourne, Australia
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, Part-2, and Part-3.
Note: this minisymposia has been accepted, but the abstracts have not yet been finalized.
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CDEV-01
Mathematical and computational ophthalmology: insights from data-driven multiscale modelling of the eye
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CDEV-01
Organized by: Laura Wadkin (Newcastle University), Patrick Parkinson (Newcastle University)
- Laura Wadkin Newcastle University "Optimising stem cell therapies for corneal damage: insights from clinical trial image analysis"
- Joel Vanin Biocomplexity Institute/Indiana University Bloomington "V-Cornea: A Multiscale Virtual Tissue Approach to Modeling Corneal Biology"
- Patricia Lamirande University of Oxford "Mathematical modelling of ocular drug delivery using mean first passage time"
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CDEV-03
(Part 1)
From data to mechanisms: advancement in modeling in cell and developmental biology
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CDEV-03
(Part 1)
Organized by: Keisha Cook, Anna Nelson (Clemson University), Alessandra Bonfanti (Politecnico di Milano) Giulia Celora (University of Oxford) Kelsey Gasior (University of Notre Dame) Qixuan Wang (University of California, Riverside)
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Khanh Dao Duc University of British Columbia "Optimal Transport based metrics and statistics for quantifying cell shape heterogeneity"
- Peijie Zhou Peking University "Towards AI Virtual Cell Through Dynamical Generative Modeling of Single-cell Omics Data"
- Amanda Alexander University of Houston "Persistence of plasmid DNA in spatially organized bacterial populations"
- Grace McLaughlin University of North Carolina, Chapel Hill "Modeling Asynchronous Nuclear Division in Fungal Cells"
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IMMU-01
(Part 1)
New approaches to infectious disease immunity for model-informed vaccine development
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IMMU-01
(Part 1)
Organized by: Terry Easlick (Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine), Morgan Craig, Univeristé de Montréal/Centre de recherche Azrieli du CHU Sainte-Justine
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Jane Heffernan York University "The Malaria Parasite Life-Cycle"
- Solène Hegarty-Cremer Université de Montréal "Analysing Immune Dysregulation in Vitamin A Deficient Mice During Influenza A Infection"
- Stanca M. Ciupe Virginia Tech "Immune system onset and reaction against viral diseases"
- Terry Easlick Université de Montréal "Stochastic Methods for modelling antigen-specific cell-mediated immune response"
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IMMU-04
(Part 1)
Multiscale modelling in infectious diseases
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IMMU-04
(Part 1)
Organized by: Dr Macauely Locke (Los Alamos National Laboratory), Dr Jasmine Kreig, Dr Aurelien Marc, Los Alamos National Laboratory
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Aurelien Marc Los Alamos National Laboratory "Modelling shows novel polymerase inhibitor AT-511 (Bemnifosbuvir) demonstrates dual activity against both production and assembly/secretion of hepatitis C virus."
- Nathanael Hoze IAME "Integrating multiscale mathematical modeling and serology to unravel antibody dynamics and infection risk"
- Quiyana Murphy Virginia tech "Understanding antibody durability and magnitude following vaccination against SARS-CoV-2"
- Grant Lythe University of Leeds "Models of bursting and budding"
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MEPI-07
(Part 1)
Recent Trends in Mathematics of Vector-borne Diseases and Control
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MEPI-07
(Part 1)
Organized by: Abba Gumel (University of Maryland), Alex Safsten, Arnaja Mitra (both University of Maryland)
Note: this minisymposia has multiple sessions. The other sessions are: Part-2, and Part-3.
- Michael Robert Virginia Tech "Climate-informed mitigation of mosquito-borne disease: the case of dengue in an emerging environment"
- Salihu Musa University of Maryland "Mathematical modeling of the geo-spatial dynamics of Lyme disease under various climate change projection scenarios"
- Kathleen Hoffman University of Maryland Baltimore County "Parameter Sensitivity, Identifiability, & Estimation for a Data-Driven Model of Malaria"
- Abba Gumel University of Maryland "Recent advances and challenges in the mathematics of malaria dynamics"
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MEPI-08
(Part 2)
Modeling Complex Adaptive Systems in Life and Social Sciences
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MEPI-08
(Part 2)
Organized by: Yun Kang (Arizona State University), Tao Feng, Yangzhou University & University of Alberta
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, and Part-3.
- Yaqi Chen Harbin Institute of Technology & University of Alberta "Well-Posedness and Dynamical Behavior of a Two-Species Reaction-Diffusion Model with Nonlocal Perception"
- Shan Gao University of Alberta "Early detection of disease outbreaks and non-outbreaks using incidence data: A framework using feature-based time series classification and machine learning"
- Bo-Wei Qin Fudan University "Polarization Does Not Necessarily Imply Conflict: Modeling and Modulating Pattern Boundaries of Opinion Dynamics"
- Joan Ponce Arizona State University "Extreme geographic misalignment of healthcare resources and HIV treatment deserts in Malawi"
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MFBM-04
Interaction laws to collective behaviour: Inferring population dynamics
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MFBM-04
Organized by: Rebecca Crossley, Stéphanie Abo (University of Oxford), University of Oxford
- John Nardini The College of New Jersey "Decoding agent-based model behavior: novel methods for prediction and global sensitivity analysis"
- Jinchao Feng Great Bay University "A Sparse Bayesian Learning Algorithm for Estimation of Interaction Kernels in Motsch-Tadmor Model"
- Seungwoong Ha Santa Fe Institute "Toward a Data-Centric Understanding of Collective Dynamics"
- Ming Guo Massachusetts Institute of Technology "Collective curvature sensing and fluidity in three-dimensional multicellular systems"
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MFBM-05
(Part 2)
Data-driven modeling in biology and medicine
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MFBM-05
(Part 2)
Organized by: Kang-Ling Liao (University of Manitoba), Wenrui Hao, Pennsylvania State University
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Kang-Ling Liao University of Manitoba "Mathematical Modeling of Breast Cancer Treatment with Radiation, Anti-estrogen, and Immune Checkpoint Inhibitor"
- Tracy Stepien University of Florida "Modeling Tumor-Immune Interactions in the Glioblastoma Microenvironment"
- Wenrui Hao Pennsylvania State University "Data-Driven Modeling in Alzheimer's Disease"
- Negar Mohammadnejad University of Alberta "Strategies for Optimizing the Efficacy of Oncolytic Virus–Immune System Interactions"
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MFBM-15
Calibrating and Relating agent based models to spatial data
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MFBM-15
Organized by: Sydney Ackermann, Ramanarayanan Kizhuttil, Samrat Sohel Mondal (Wodarz lab) (University of California, San Diego)
Note: this minisymposia has been accepted, but the abstracts have not yet been finalized.
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MFBM-18
(Part 1)
Geometrical and Topological Methods for Data-Driven Modeling
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MFBM-18
(Part 1)
Organized by: Dhananjay Bhaskar (Yale University), Bernadette Stolz-Pretzer
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Katherine Benjamin University of Oxford "Topological methods for subcellular spatial transcriptomics"
- Veronica Ciocanel Duke University "Unraveling aster and ring structures in cell models of dynamic actin filaments using topological data analysis"
- Robert McDonald University of Oxford "Topological model selection: a case-study in tumour-induced angiogenesis"
- Nan Wu University of Texas at Dallas "Adaptive Bayesian regression on manifold"
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ONCO-01
Data-informed mathematical modeling in cancer and development
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ONCO-01
Organized by: Changhan He (University of California, Irvine), Chengyue Wu, University of Texas MD Anderson Cancer Center
- Lifeng Han Tulane University "Calibrate a phenotype-structured population model with cell viability data to study drug resistance in cancer treatment"
- Wenjun Zhao Wake Forest University "Dynamical GRN inference via optimal transport"
- Qixuan Wang University of California, Riverside "Hair follicle cell fate regulations and the effect on the follicle growth control"
- Axel Almet University of California, Irvine "Systems modeling of cellular senescence using single-cell transcriptomics"
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ONCO-08
(Part 1)
Decoding Drug-Induced Persistence: Experiments, Models, and Optimal Drug Scheduling
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ONCO-08
(Part 1)
Organized by: Einar Bjarki Gunnarsson (Science Institute, University of Iceland), Maximilian Strobl (Cleveland Clinic, USA, stroblm@ccf.org)
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Einar Bjarki Gunnarsson Science Institute, University of Iceland "Decoding drug-induced persistence: Integrating theory with experiments and optimizing dosing protocols"
- Mattia Corigliano IFOM - The AIRC Institute of Molecular Oncology, Milan, Italy "Optimal treatment for drug-induced cancer persisters involves release periods and intermediate drug doses"
- Irina Kareva Northeastern University "Dosing Strategies for Bispecifics with a Bell-Shaped Efficacy Curve: What Looks Like Resistance May Be Corrected Through Schedule Adjustments"
- Tatiana Miti Moffitt Cancer Center & Research Institute "ABM studies on the role of the drug-sheltering effects of stroma on the emergence of resistance"
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OTHE-01
Information theory, fitness, and semantics in biological information processing
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OTHE-01
Organized by: Andrew Eckford (Department of Electrical Engineering and Computer Science, York University, Toronto)
- Massimiliano Pierobon University of Nebraska-Lincoln "On the Usefulness and Subjectivity of Life-supporting Information"
- Alexander Moffett Northeastern University "Evolution of Environmental Sensing"
- Andrew Eckford York University "Kelly Bets and Single-Letter Codes: Optimal Information Processing in Natural Systems"
- Peter Thomas Case Western Reserve University "Tradeoffs in the energetic value of neuromodulation in a closed-loop neuromechanical system"
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OTHE-04
(Part 2)
Mathematical frontiers in the analysis of biological systems with kinetic effects and spatial diffusion
Timeblock: MS04
OTHE-04
(Part 2)
Organized by: Fanze Kong (University of Washington), Michael Jeffrey Ward and University of British Columbia
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Fanze Kong University of Washington "Spike Dynamics in Several Keller-Segel Models with Logistic Growth"
- Mohammad El Smaily University of Northern British Columbia "A Wolbachia infection model with free boundary"
- Michael Ward University of British Columbia "Diffusion-Induced Synchrony for a Cell-Bulk Compartmental Reaction-Diffusion System in 3-D"
- Shuangquan Xie Hunan University "Spiky patterns and their dynamics in a three-component food chain system"