In many developmental and disease processes, tissues shift from solid-like to fluid-like mechanical behavior to enable large-scale tissue flows. A key unresolved question is how different organisms regulate this transition by controlling cell-scale properties. In both zebrafish and chick, a fluid-to-solid transition occurs in the presomitic mesoderm, the driving force behind posterior body axis elongation. In zebrafish, this transition is well explained by a soft particle model that undergoes a jamming/unjamming transition, driven by small changes in global volume fraction and active fluctuations, without considering cell shape or deformation. However, the tissue architecture in chick is distinct from zebrafish, with large extracellular gaps and stellate cells with distinct arm junctions, indicating that even closely related species may have evolved different mechanisms to cross a fluid/solid transition. Here, we develop a computational model to understand the essential features needed to predict the unique properties of low density, but highly connected, stellate tissues, which tissue rounding experiments demonstrate are fluid-like on long timescale. We compare short-time retraction velocities and tissue relaxation due to laser ablation between experiment and simulation to determine whether the mesenchyme is under tension. Additionally, we propose novel glassy dynamics can be controlled not via density changes but instead by cell-cell adhesion unbinding kinetics coupled with contact inhibition of locomotion, and propose new experiments to test these ideas.
Minisymposia: MS05
Wednesday, July 16 at 10:20am
Minisymposia: MS05
Timeblock: MS05
CDEV-06
(Part 1)
Modeling the Role of Geometry and Topology in Shaping Cell Behavior, Function, and Tissue Patterns
Timeblock: MS05
CDEV-06
(Part 1)
Organized by: Fabian Spill (University of Birmingham), Anotida Madzvamuse, University of British Columbia
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Alex Grigas Syracuse University "Modeling fluidity in stellate mesenchymal tissues"
- Sharon Minsuk Indiana U., Bloomington "The Role of Embryo, Tissue, and Cell Shape in Morphogenesis: Modeling the Cellular Dynamics of Tissue Deformation"
- Margherita De Marzio Harvard Medical School and Brigham and Women’s Hospital "Understanding the Role of Surface Curvature on Epithelial Plasticity"
- Padmini Rangamani UCSD "Nanoscale curvature of the plasma membrane regulates mechanoadaptation through nuclear deformation and rupture"
Timeblock: MS05
CDEV-07
(Part 1)
Modeling cell migration at multiple scales
Timeblock: MS05
CDEV-07
(Part 1)
Organized by: Jared Barber (Indiana University Indianapolis), Luoding Zhu
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Calina Copos Northeastern University "Migration modes of small cell groups: which forces govern their emergent movement?"
- Yuehui Xu Indiana University Indianapolis "A 3D Viscoelastic Model of Cell Migration with Mechanical and Adhesive Forces"
- John Dallon Brigham Young University "Modeling differential cell motion in the Dictyostelium discoideum slug"
Timeblock: MS05
ECOP-09
Nonlocal Models: Progress and Challenges in Analysis, Applications and Numerics
Timeblock: MS05
ECOP-09
Organized by: Valeria GIunta (Swansea University), Yurij Salmaniw - University of Oxford
- Raluca Eftimie Université de Franche-Comté, France "Mathematical models for non-local cell-cell interactions in health and disease"
- Junping Shi College of William & Mary, Williamsburg, USA "Biological Aggregations from Spatial Memory and Nonlocal Advection"
- Sara Bernardi Politecnico di Torino, Italy "Variations in nonlocal interaction range lead to emergent chase-and-run in heterogeneous populations"
- Jun Jewell University of Oxford, UK "Long-ranged interactions shape populations and patterns in biology"
Timeblock: MS05
IMMU-03
(Part 2)
Immune Responses to Viral Infections and Vaccines
Timeblock: MS05
IMMU-03
(Part 2)
Organized by: Veronika I. Zarnitsyna (Emory University), Esteban Hernandez Vargas, University of Idaho
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Grant Lythe University of Leeds "TCR repertoire and cross-reactivity"
- Dylan Hull-Nye Washington State University "Derivation of mathematical relationship between cytotoxic T lymphocyte (CTL) and antibody production rates for immune control in lentiviral infection"
- Alexis Erich S. Almocera University of the Philippines Mindanao "Hopf Bifurcations Unravel Complex Antibody Dynamics in COVID-19 Patients"
- Reagan Johnson University of Idaho "Modeling Rhinovirus mediated protection against lethal influenza"
Timeblock: MS05
MEPI-05
(Part 2)
Mathematical Modelling of Human Behaviour
Timeblock: MS05
MEPI-05
(Part 2)
Organized by: Iain Moyles (York University), Rebecca Tyson, University of British Columbia Okanagan
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Sarah Machado-Marques York University "Considering the effects of pair formation dynamics on mpox and HIV co-infection in the gbMSM community"
- Bridgette Amoako University of Guelph "Sexual Behaviour and Mpox Transmission in an Agent Based Model"
- Clark KendrickGo Ateneo de Manila University "Exploring Mathematical Techniques in Collective Behaviour and Decision Making in Animal Groups"
Timeblock: MS05
MEPI-07
(Part 2)
Recent Trends in Mathematics of Vector-borne Diseases and Control
Timeblock: MS05
MEPI-07
(Part 2)
Organized by: Abba Gumel (University of Maryland), Alex Safsten, Arnaja Mitra (both University of Maryland)
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, and Part-3.
- Katharine Gurski Howard University "Building a Model for Seasonal Malaria Chemoprevention and Drug Resistance"
- Yves Dumont French Agricultural Research Centre for International Development "Reducing nuisances or minimizing epidemiological risks: which is the best choice with the Sterile Insect Technique?"
- Alex Safsten University of Maryland "Leveraging inter-species competition to improve the effectiveness of the sterile insect technique"
- Zhoulin Qu University of Texas San Antonio "Multistage spatial model for informing release of Wolbachia-infected mosquitoes as disease control"
Timeblock: MS05
MEPI-08
(Part 3)
Modeling Complex Adaptive Systems in Life and Social Sciences
Timeblock: MS05
MEPI-08
(Part 3)
Organized by: Yun Kang (Arizona State University), Tao Feng, Yangzhou University & University of Alberta
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, and Part-2.
- Matthew Wheeler University of Florida "Linking Network Architecture to Dynamic Behavior"
- Xingfu Zou University of Western Ontario "Infection forces mediated by behaviour changes with demonstration by a DDE model"
- Daniel B. Reeves Fred Hutchinson Cancer Center "Modeling HIV reservoir ecology and selection through the lens of CD4+ T cell kinetics"
Timeblock: MS05
MEPI-09
Integrating Health Economics and Infectious Disease Modelling: Methods and Examples for Informing Policy
Timeblock: MS05
MEPI-09
Organized by: Dr. Marie Varughese (Institute of Health Economics and University of Alberta), Dr. Ellen Rafferty (erafferty@ihe.ca)– Institute of Health Economics and University of Alberta
Note: this minisymposia has been accepted, but the abstracts have not yet been finalized.
Timeblock: MS05
MFBM-07
(Part 1)
Stochastic Methods for Biochemical Reaction Networks
Timeblock: MS05
MFBM-07
(Part 1)
Organized by: Hye-Won Kang (University of Maryland Baltimore County), Arnab Ganguly, Louisiana State University, aganguly@lsu.edu
Note: this minisymposia has multiple sessions. The other sessions are: Part-2, and Part-3.
- Ruth J Williams University of California San Diego "Stochastic Analysis of Markov Chain Models for Chromatin Dynamics"
- Grzegorz Rempala Ohio State University "Likelihood Functions for Individual-Level Chemical Reaction Models"
- Mark Flegg Monash University "Stochastic Simulation of Reaction Networks with Well-Mixed Clustered Agents"
- Hye-Won Kang University of Maryland Baltimore County "Multiscale Approximation and Parameter Estimation in Stochastic Models of the Glycolytic Pathway"
Timeblock: MS05
MFBM-13
(Part 3)
Modern methods in the data-driven modeling of biological systems
Timeblock: MS05
MFBM-13
(Part 3)
Organized by: Cody FitzGerald (Northwestern University), Rainey Lyons (CU Boulder), Nora Heitzman-Breen (CU Boulder), Susan Rogowski (NCSU)
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, Part-2, and Part-4.
Note: this minisymposia has been accepted, but the abstracts have not yet been finalized.
Timeblock: MS05
MFBM-16
Mathematical Modelling in Disease and Therapy: Integrating Quantitative Frameworks for Deeper Insights
Timeblock: MS05
MFBM-16
Organized by: Maria Kleshnina (Queensland University of Technology), Mason Lacy (Queensland University of Technology), Luke Filippini (Queensland University of Technology)
- Luke Filippini Queensland University of Technology "Data-informed stochastic frameworks of anisotropic movement in the brain"
- Moriah Echlin Tampere University "Using Single-Cell Data-driven Boolean Network Models to Analyze Prostate Cancer Progression"
- Louise Spekking TU Delft "Improving cancer therapy through migrastatics and estimating tumor composition"
- Noa Levi University of Melbourne "Leveraging algebraic approaches to inform therapeutic intervention"
Timeblock: MS05
ONCO-03
(Part 1)
MathOnco Subgroup Mini-Symposium: At the Interface of Modeling and Machine Learning
Timeblock: MS05
ONCO-03
(Part 1)
Organized by: Jana Gevertz (The College of New Jersey), Thomas Hillen (University of Alberta), Linh Huynh (Dartmouth College)
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Thomas E. Yankeelov The University of Texas at Austin "Integrating mechanism-based and data driven modeling to predict breast cancer response to neoadjuvant chemotherapy"
- Paul Macklin Indiana University "Integrating high-throughput exploration and learning with agent-based models of cancer"
- Adam L. MacLean University of Southern California "Dynamic rewiring of cell-cell interaction networks in metastatic TMEs to empower checkpoint inhibition"
- Venkata Manem Centre de Recherche du CHU de Québec; Université Laval, Canada Université Laval, Canada "Beyond the One-Size-Fits-All Paradigm: Leveraging Bioinformatics and AI to Advance Biomarker-Guided Oncology."
Timeblock: MS05
OTHE-02
Emerging Technologies in Biomedical Computational Modeling and Measurement
Timeblock: MS05
OTHE-02
Organized by: Joanna Wares (University of Richmond), Luis Melara, Shippensburg University
- Luis Melara Shippensburg University "Optimal Bandwith Selection in Bio-FET Measurements"
- Joanna R. Wares University of Richmond "Comparison of Virtual Clinical Trial Techniques"
Timeblock: MS05
OTHE-07
(Part 2)
Bioinference: diverse approaches to inference and identifiability in biology
Timeblock: MS05
OTHE-07
(Part 2)
Organized by: Ioana Bouros (University of Oxford), Alexander Browning, University of Melbourne
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Hyukpyo Hong University of Wisconsin–Madison "Inferring delays in partially observed gene regulation processes"
- Hui Jia Farm University of Oxford "Ensuring parameter identifiability in cardiac cell models is an essential prerequisite for reliable prediction"
- Marisa Eisenberg University of Michigan "Identifiability, uncertainty, and model reduction in mathematical biology"
- Tyler Cassidy University of Leeds "Parameter estimation and identifiability from clinical data in viral dynamics models"
Timeblock: MS05
OTHE-09
Modeling Social and Political Ecosystems
Timeblock: MS05
OTHE-09
Organized by: David Sabin-Miller (University of Michigan)
- Heather Zinn Brooks Harvey Mudd College "An opinion reproduction number for infodemics in a bounded-confidence content-spreading process on networks"
- Olivia Chu Bryn Mawr College "Adaptive network models and the dynamics of political polarization and social activism"
- Alexandria Volkening Purdue University " Forecasting U.S. elections with compartmental models of infection"
- David Sabin-Miller University of Michigan "Data-driven modeling of US information-ideological dynamics"