The resolution of chronic inflammation involves a dynamic balance between cell death and the clearance of dying cells via efferocytosis. In nonresolving atherosclerotic plaques, this balance is disrupted due to the the impairment of normal macrophage function. The accumulation of excess cholesterol by plaque macrophages promotes unprogrammed necrotic cell death, and the resulting necrotic material is less readily cleared by live macrophages. Macrophage efferocytic ability itself can also become impaired. The combination of poor efferocytosis and increased cell death rates can overwhelm live macrophages' ability to clear dying cells, eventually leading to the formation of a necrotic core.
In this talk, we present a free boundary multiphase model for the early development of atherosclerotic tissue, where macrophages can undergo both apoptotic (programmed) and necrotic cell death. We show how high rates of cell death and low rates of efferocytosis can lead to a plaque populated mostly by dead material. We use multiple timescale analysis of a related spatially homogeneous ODE model to analyse how plaque tissue composition evolves in the short and long term, where the dynamics are dominated by apoptosis and necrosis respectively. We show in particular that healthy efferocytosis can lead to a short timescale equilibrium where live macrophages and apoptotic cells coexist, and that the onset of necrosis affects the stability of this equilibrium. We also consider how the availability (or lack thereof) of live cells in the deep plaque impacts cell emigration and plaque growth.
Minisymposia: MS02
Monday, July 14 at 4:00pm
Minisymposia: MS02
Session: MS02 Room: Salon 4
CARD-02
(Part 2)
Novel multiscale and multisystem approaches to cardiovascular modeling and simulation
Session: MS02 Room: Salon 4
CARD-02
(Part 2)
Organized by: Mitchel J. Colebank (University of South Carolina), Vijay Rajagopal, The University of Melbourne, Australia
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, and Part-3.
- Ishraq U Ahmed University of Sydney "Death out of balance: cell necrosis and defective efferocytosis in a model for early atherosclerotic plaque tissue"
- Pak-Wing Fok University of Delaware "Impact of Medial Calcification on Arterial Mechanics and Hemodynamics"
- Laura Ellwein Fix Virginia Commonwealth University "A closed-loop system-level model of cerebrovascular reactivity"
- Liam Murray The University of Melbourne "Myofibril networks produce shear stress in sheep cardiomyocytes"
Session: MS02 Room: Salon 5
ECOP-01
Mathematical Models of Biofilm Processes
Session: MS02 Room: Salon 5
ECOP-01
Organized by: Hermann Eberl (University of Guelph), John Ward
- Maria Rosaria Mattei University of Naples Federico II "A modeling and simulation study of horizontal gene transfer in biofilms"
- Rachana Mandal University of Guelph "Modeling and Simulation of Biofilm Growth in a Counter-Diffusion System, Coupled with Biozone Formation in the Aqueous Phase by Chemotactic Bacteria"
- Fabiana Russo Naples University "Modeling biofilm growth and microbially induced corrosion in wastewater concrete pipes: a double free boundary problem"
- Blessing Emerenini Rochester Institute of Technology "Modeling Biofilm Induced Corrosion Inhibition - what do we know?"
Session: MS02 Room: Salon 9
ECOP-05
(Part 2)
Celebrating 60 Years of Excellence: Honoring Yang Kuang’s Contributions to Mathematical Biology
Session: MS02 Room: Salon 9
ECOP-05
(Part 2)
Organized by: Tin Phan (Los Alamos National Laboratory), Yun Kang (Arizona State University); Tracy Stepien (University of Florida)
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, Part-3, and Part-4.
- Angela Peace Texas Tech University "Nutrient-Driven Adaptive Foraging Behaviors"
- Tin Phan Los Alamos National Labs "Drifting through the land of mathematical biology"
- Irakli Loladze Bryan College of Health Sciences "From Information Strings to Ocean Stoichiometry: Why Life's Atomic Constraints Drive Convergence to the Redfield Ratio"
- Bruce Pell Lawrence Technological University "Stability Switching Induced by Cross-Immunity in a Two-Strain Virus Competition Model with Wastewater Data Validation"
Session: MS02 Room: Salon 17/18
ECOP-08
Ecological aspects of vector-borne disease
Session: MS02 Room: Salon 17/18
ECOP-08
Organized by: Abigail Barlow (The University of Bath), n/a
- Abby Barlow The University of Bath "Integrated tick management strategies in fragmented peridomestic environments"
- Folashade B. Agusto University of Kansas "Modeling the effect of lethal and non-lethal predation on the dynamics of ticks and tick-borne ehrlichiosis disease"
- Kyle Dahlin Virginia Tech "Down with the sickness: modelling the effect of disturbed blood-feeding on mosquito-borne disease transmission"
- Christina Cobbold The University of Glasgow "Incorporating adult age dynamics into mosquito population models: implications for predicting abundances in changing climates"
Session: MS02 Room: Salon 12
MEPI-01
(Part 2)
Scenario Modeling to Inform Public Policymaking
Session: MS02 Room: Salon 12
MEPI-01
(Part 2)
Organized by: Zhilan Feng (National Science Foundation), John W Glasser, The US Centers for Disease Control and Prevention (CDC)
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Junling Ma University of Victoria "Assess the effectiveness of Contact Tracing during the early stage of a pandemic"
- Sen Pei Columbia University "Addressing the challenge of imperfect observation processes in epidemic modeling"
- Troy Day Queens University "Modelling the distribution of fitness effects of new mutations"
- Zhilan Feng National Science Foundation "Mechanistic models are hypotheses"
Session: MS02 Room: Salon 6
MEPI-06
(Part 1)
Recent Advances in Dynamics of Human Behavior and Epidemics
Session: MS02 Room: Salon 6
MEPI-06
(Part 1)
Organized by: Abba Gumel (University of Maryland), Alex Safsten, Alice Oveson (both University of Maryland)
Note: this minisymposia has multiple sessions. The other sessions are: Part-2, and Part-3.
- Navid Ghaffarzadegan Virginia Tech "Pandemics and People: Modeling Outbreaks with Behavior in the Loop"
- Jane Heffernan York University "Modelling Positive and Negative Behaviour Change"
- Sefah Frimpong University of Waterloo "COVID-19 Coupled Behaviour-Disease Model"
- Binod Pant Northeastern University "Analyzing human behavior data and modeling the impact of human behavior on SARS-CoV-2 transmission dynamics"
Session: MS02 Room: Salon 1
MEPI-12
Incorporating control into infectious disease models
Session: MS02 Room: Salon 1
MEPI-12
Organized by: Michael A. Robert (Virginia Tech)
- Stacey Smith? University of Ottawa "Could COVID-19 mask and vaccine mandates have made a difference if they were rolled out earlier?"
- Indunil M. Hewage Washington State University "The population-level impact of COVID-19 vaccines: Investigating the different aspects of vaccine effectiveness."
- Tin Phan Los Alamos National Labs "Mathematical modeling reveals that latently infected cells reactivated by AZD5582 via the non-canonical NF-κB pathway differ substantially from productively infected cells"
Session: MS02 Room: Salon 11
MFBM-10
(Part 2)
Flow-Kick Dynamics in Population Biology: Bridging Continuous and Discrete Processes
Session: MS02 Room: Salon 11
MFBM-10
(Part 2)
Organized by: Sebastian Schreiber (University of California, Davis)
Note: this minisymposia has multiple sessions. The other session is: and Part-1.
- Junping Shi College of William and Mary "Effect of rotational grazing on plant and animal production"
- Kate Meyers Carleton College "From deluges to drizzle: continuous limits of flow-kick models"
- Rebecca Tyson University of British Columbia, Okanagan "Host-parasitoid systems are vulnerable to extinction via P-tipping: Forest Tent Caterpillar as an example"
- Sebastian Schreiber University of California, Davis "Coexistence and extinction in flow kick systems via Lyapunov exponents"
Session: MS02 Room: Salon 10
MFBM-13
(Part 2)
Modern methods in the data-driven modeling of biological systems
Session: MS02 Room: Salon 10
MFBM-13
(Part 2)
Organized by: Cody FitzGerald (Northwestern University), Rainey Lyons (CU Boulder), Nora Heitzman-Breen (CU Boulder), Susan Rogowski (NCSU)
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, Part-3, and Part-4.
- Alexandria Volkening Purdue "Combining different approaches to topological data analysis to quantify agent-based patterns"
- Yue Liu Purdue "Bayesian parameter inference in agent-based models of zebrafish patterns using TDA"
- Kyle Nguyen NCSU "Model-form Error Correction using Universal Differential Equations for an Agent-Based Model of Infectious Disease"
- Alyssa Wenzel NCSU "Topologically-based parameter inference for agent-based model selection from spatiotemporal cellular data"
Session: MS02 Room: Salon 8
MFBM-14
(Part 2)
Multicellular Agent-Based Modelling - The OpenVT Project
Session: MS02 Room: Salon 8
MFBM-14
(Part 2)
Organized by: James Osborne (University of Melbourne), James Glazier (Indiana University) Yi Jiang (Georgia State University)
Note: this minisymposia has multiple sessions. The other sessions are: Part-1, and Part-3.
- Rajendra Singh Negi Syracuse University, USA "Multicellular modeling of how myosin localization impacts symmetry-breaking in zebrafish embryonic development"
- Claire Miller Auckland Bioengineering Institute, NEW ZEALAND "Multicellular modelling of endometrial cell invasion in endometriosis lesion onset"
- TJ Sego University of Florida, USA "Quantitative Reproducibility at Scale: A Federated, Standardizable Approach"
- Eran Agmon University of Connecticut, USA "Multicellular Schema with Vivarium"
Session: MS02 Room: Salon 19/20
NEUR-02
Modeling of Neurodegenerative Diseases
Session: MS02 Room: Salon 19/20
NEUR-02
Organized by: Laurent PUJO-MENJOUET and Suzanne SINDI (Claude Bernard Lyon 1 University (Lyon, FRANCE))
- Théo LOUREAUX University of California, Merced "Modeling the Prion Aggregation Process During Polymerization Experiments Using Delay Differential Equations"
- Ashish Raj University of California San Francisco "Biophysical modeling of pathology progression in dementia and its implementation using physics-informed neural networks"
- Human Rezaei INRAE, Jouy-en-Josas FRANCE "Intrinsic Dynamics and Deterministic Diversification Drive a New Model of Prion Replication and Dissemination"
- Laurent Pujo-Menjouet University Claude Bernard Lyon 1 - Camille Jordan Institute "Modeling the formation of perinuclear crowns made of agglutinated ATM proteins observed in fibroblasts from patients affected by Alzheimer’s disease"
Session: MS02 Room: Salon 13/14
ONCO-06
(Part 1)
Data-driven integration and modeling of cellular processes in cell motility and cancer progression: Experiments and mathematical models
Session: MS02 Room: Salon 13/14
ONCO-06
(Part 1)
Organized by: Yangjin Kim (Brown University and Konkuk University), Magdalena Stolarska at University of St. Thomas
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Magda Stolarska University of St. Thomas "A mathematical model of active cortical stress generation and its effect on cell movement"
- Dumitru Trucu University of Dundee "Advancements in multiscale modelling for glioblastoma: emergence of 'on-the-fly' non-local isotropic-to-anisotropic transition in cell population transport"
- Padmini Rangamani University of California San Diego "Modeling collagen fibril degradation as a function of matrix microarchitecture"
- Noe Mercado Warren Alpert Medical School, Brown University "Impact of Cytomegalovirus on Glioblastoma progression"
Session: MS02 Room: Salon 15/16
OTHE-04
(Part 1)
Mathematical frontiers in the analysis of biological systems with kinetic effects and spatial diffusion
Session: MS02 Room: Salon 15/16
OTHE-04
(Part 1)
Organized by: Fanze Kong (University of Washington), Michael Jeffrey Ward and University of British Columbia
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Jack Hughes University of British Columbia " Pulses, Waves, and Mesas in Mass Conserved Reaction-Diffusion Media: From Theory to Actin Polymerization"
- Thomas Hillen University of Alberta "Mean First Passage Times for Transport Equations"
- Chunyi Gai The University of Northern British Columbia "An Asymptotic Analysis of Spike Self-Replication and Spike Nucleation of Reaction-Diffusion Patterns on Growing 1-D Domains"
- Alan Lindsay University of Notre Dame "A mean first passage time theory for anisotropic velocity jump processes"
Session: MS02 Room: Salon 2
OTHE-06
(Part 1)
A New Wave of Mathematical Modeling in Medicine and Pharmacy
Session: MS02 Room: Salon 2
OTHE-06
(Part 1)
Organized by: Sungrim Seirin-Lee (Kyoto University/Graduate School of Medicine), Jaekyoung Kim (KAIST), So Miyoshi (Pfizer)
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Sungrim Seirin-Lee Kyoto University "Pathological State Inference System based on Skin Eruption Morphology for Personalized Treatments in Dermatology"
- Alexander Anderson Moffitt Cancer Center "Adaptive Therapy from Board to Bench to Bedside and Back Again"
- Adrien Hallou University of Oxford "Spatial mechano-transcriptomics: mapping at single-cell resolution mechanical forces and gene expression in tissues"
- Jae Kyoung Kim KAIST "Improving Biological Predictions: Rethinking Markovian and Diffusion Assumptions"
Session: MS02 Room: Salon 3
OTHE-10
(Part 1)
Emerging areas in Mathematical Biology: Celebrating research from the Mathematical Biosciences Institute
Session: MS02 Room: Salon 3
OTHE-10
(Part 1)
Organized by: Veronica Ciocanel (Duke University), Hye-Won Kang, University of Maryland Baltimore County
Note: this minisymposia has multiple sessions. The other session is: and Part-2.
- Scott McKinley Tulane University "Robust inference and model selection for particle tracking in live cells"
- Peter Kramer Rensselaer Polytechnic Institute "Molecular Mechanisms in Actively Driven Passively Crosslinked Microtubule Pairs"
- Yangyang Wang Brandeis University "A conceptual framework for modeling a latching mechanism for cell cycle regulation"
- Kasia Rejniak Moffitt Cancer Center "Data-driven models for guiding adoptive cell therapies in bladder cancer"